FORMULATION DEVELOPMENT

NASAL DRUG DELIVERY SYSTEMS

Drug delivery through the nose offers the advantage of a comparatively rapid onset of action that is essential for the treatment of e.g. pain relief, erectile dysfunction or nausea. In comparison to oral drug delivery systems a higher bioavailability of peptide drugs in particular by utilizing the thiomer-technology can be achieved. ThioMatrix is well versed in the design and development of liquid, semisolid and solid nasal drug delivery systems. The development includes:

• orientating permeation studies on nasal membranes
  
  
• evaluations of the stability of the drug on the nasal mucosa towards membrane bound enzymes
  
  
• orientating toxicity studies (cytotoxicity studies; ciliary beat frequency studies; histological examinations; etc.)
  
  
• optimisation of the delivery system
  
  
• storage stability studies
  
  
• in vivo pharmacokinetic studies in various animal species
  
  
• orientating studies in humans

Download a pdf (Nasal Drug Delivery)

Download a pdf (Non-invasive Peptide Drug Delivery)