Discovery & Development Europe 2025: Formulation & Drug Delivery Congress
July 1-2, 2025
Basel, Switzerland

Invited lecture:
Oral Delivery Of Peptide And Protein Drugs – Oral Delivery of GLP-1 Analogues

Prof. Dr. A. Bernkop-Schnürch
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8th European Cyclodextrin Conference
September 9-12, 2025
Milano, Italy

Invited lecture:
Thiolated Cyclodextrins in Drug Delivery

Prof. Dr. A. Bernkop-Schnürch
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Solubility Enhancement Studies

ThioMatrix has great experience in formulation of poorly soluble APIs. In order to overcome solubility problems, ThioMatrix has developed a rational screening platform aimed at finding cost-effective and quick solutions to support such studies. After a solubility screening and cristallinity assessment the identified poor solubility of APIs can bee enhanced by:

• solidlid-state modifications such as salt formation, particle size reduction or solid-state stabilization of the amorphous state
  
  
• addition of co-solvents
  
  
• development of lipid based systems such as microemulsions
  
  
• formation of complexes such as with cyclodextrins
  
  
• addition of additives such as surfactants or polymer
  
  
• Sufficient solubility is a prerequisite for essential in vitro analyses such as permeation studies and subsequently the development of highly efficient drug delivery systems.

Sufficient solubility is a prerequisite for essential in vitro analyses such as permeation studies and subsequently the development of highly efficient drug delivery systems.

Thiomatrix joined the EU-project TENTACLE (101191747) focusing on the use of thiomers for in situ bioprinting.
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