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Discovery & Development Europe 2025: Formulation & Drug Delivery Congress
July 1-2, 2025
Basel, Switzerland
Invited lecture:
Oral Delivery Of Peptide And Protein Drugs – Oral Delivery of GLP-1 Analogues
Prof. Dr. A. Bernkop-Schnürch
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8th European Cyclodextrin Conference
September 9-12, 2025
Milano, Italy
Invited lecture:
Thiolated Cyclodextrins in Drug Delivery
Prof. Dr. A. Bernkop-Schnürch
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 Disintegration behaviour of
tablets based on polycarbophil (PCP) and sodium carboxymethyl-cellulose (CMC) (grey bars) and of the corresponding thiolated polymers (blue bars) [Bernkop-Schnürch, A., Scholler, S., and Biebel, R.G. (2000). Development of controlled drug release systems based on polymer-cysteine conjugates. J. Cont. Rel, 66, 39].
Release profile of
fluoresein from tablets based on poly(acrylic acid) (grey graph) and from tablets based on thiolated poly(acrylic acid) (blue graph) [Hornof, M.D., Weyenberg, W., Ludwig, A., and Bernkop– Schnürch, A. (2003). A mucoadhesive ocular insert: Development and in vivo evaluation in humans. J. Cont. Rel. 89, 419].
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Controlled Drug Release
Due to a sustained drug
release, a prolonged therapeutic level of drugs exhibiting a short
elimination half-live can be maintained. Consequently the frequency of
dosing can be reduced contributing to an improved compliance. The release of
drugs out of polymeric carrier systems can be controlled by a simple
diffusion process. So far the efficacy of such delivery systems, however,
was limited by a too rapid disintegration and/or erosion of the polymeric
network [Bernkop-Schnürch, A., Scholler, S., and Biebel, R.G. (2000). Development of controlled drug release systems based on polymer-cysteine conjugates. J. Control. Release, 66, 39; Clausen, A.E., and Bernkop-Schnürch, A. (2001) Development and in vitro evaluation of a peptide drug delivery system based on thiolated polycarbophil. Pharm. Ind., 63, 312]. By using thiolated polymers this essential shortcoming can be
overcome. Because of the formation of inter- and intrachain disulfide bonds
during the swelling process, the stability of the polymeric drug carrier
matrix is strongly improved. Hence, a controlled drug release for numerous
hours is guaranteed. This controlled drug release has also been demonstrated
by studies in human volunteers.
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News
Thiomatrix joined the EU-project TENTACLE (101191747) focusing on the use of thiomers for in situ bioprinting.
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